DPP6 Loss Impacts Hippocampal Synaptic Development and Induces Behavioral Impairments in Recognition, Learning and Memory

نویسندگان

  • Lin Lin
  • Jonathan G. Murphy
  • Rose-Marie Karlsson
  • Ronald S. Petralia
  • Jakob J. Gutzmann
  • Daniel Abebe
  • Ya-Xian Wang
  • Heather A. Cameron
  • Dax A. Hoffman
چکیده

Molecular Neurophysiology and Biophysics Section, Program in Developmental Neuroscience, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States, Section on Neuroplasticity, National Institute of Mental Health, Bethesda, MD, United States, Advanced Imaging Core, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Bethesda, MD, United States

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Crocin Improved Learning and Memory Impairments in Streptozotocin-Induced Diabetic Rats

Objective(s): Crocin influences many biological functions including memory and learning. The present study was aimed to investigate the effects of crocin on learning and memory impairments in streptozotocine-induced diabetic rats. Materials and Methods: Diabetes was induced by intraperitoneal (IP) injection of streptozotocin (STZ, 45 mg/kg). Transfer latency (TL) paradigm in elevated plus-maze ...

متن کامل

P3: Mechanisms of TrkB-Mediated Hippocampal Long-Term Potentiation in Learning and Memory

Long-term potentiation (LTP) is a process that certain types of synaptic stimulation lead to a long-lasting enhancement in the strength of synaptic transmission. Studies in recent years indicate the importance of molecular pathways in the development of memory and learning. Tropomyosin receptor kinase B (TrkB) is a member of the neurotrophin receptor tyrosine kinase family, that its ligand is b...

متن کامل

The role of hippocampal nitric oxide in passive avoidance learning

Abstract: Introduction: Nitric oxide (NO) is a retrograde messenger in hippocampal synaptic plasticity which involves in learning and memory processes. Previous studies revealed that hippocampal pyramidal cells contain NO synthase (NOS) enzyme which produce NO and could be a promising target to evaluate the role of NO in brain cognitive functions. So in this study, using NOS inhibitor (L-NAME)...

متن کامل

Proteome Analysis of Rat Hippocampus Following Morphine-induced Amnesia and State-dependent Learning

Morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. Whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of morphine ...

متن کامل

Proteome Analysis of Rat Hippocampus Following Morphine-induced Amnesia and State-dependent Learning

Morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. Whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of morphine ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2018